Avantor® are pleased to announce we have acquired the worldwide exclusive rights to manufacture Vydac®, Alltima®, Alltima® HP, Prevail™, Apollo™, Allsep®, Apex™ and Genesis™ analytical HPLC column ranges from Grace/Alltech. Avantor® have now commenced manufacture of these columns to the same exacting manufacturing protocols and to identical specifications previously used by Grace/Alltech. Part numbers also remain unaffected by the acquisition.
Avantor® manufacture the ultra-inert Avantor® ACE® UHPLC/HPLC column range. Avantor® ACE® phases incorporate the latest developments in LC stationary phase design, providing chromatographers with more choices for alternative selectivity, without compromising stability or robustness. Avantor® ACE® LC phases have been specifically designed to help solve chromatographic challenges and include the unique C18-AR, C18-PFP, C18-Amide, CN-ES, SuperC18 and SuperPhenylHexyl phases, as well as a wide range of other 100 Å and 300 Å phases. Discover how Avantor® ACE® selectivities can help you with your chromatographic challenges. Avantor® ACE® – superior LC columns.
MonoCap C18 HighResolution 2000 is a 2-meter length monolithic silica capillary column which is designed for identifying extremely high number of peptides/proteins for proteome research via LC-MS/MS. MonoCap HILIC-UP is an important addition to the MonoCap C18 HighResolution 2000 column series. MonoCap HILIC-UP can retain highly hydrophilic peptides/proteins which may lead to discovering new peptides/proteins where a C18 phase couldn’t identify. In HILIC, the higher the organic concentration, the greater the retention of more polar analytes. One of the biggest benefits of HILIC mode is, a high organic solvent concentration of the mobile phase will lead to a high sensitivity LC-MS/MS analysis.
Generally, silica based columns are mechanically stable and provide high efficiencies, however, they cannot be used under alkaline conditions and their residual silanol groups tend to adsorb organic bases. InertSustain employs a radically new type of silica, in which the surface of the silica is uniquely modified, enabling precise control of the silica properties. InertSustain inherits the advantages of all the current Inertsil HPLC columns (e.g., extremely low operating back pressure, superior inertness to typically any analytes, high efficiency and compatibility with a wide range of solvents), but now can be used for wide pH analysis with consistent performance from column to column and lot to lot.
The InertSustain Serie has the following columns available; InertSustain C18, InertSustain AQ-C18, InertSustainSwift C18, InertSustainSwift C8, InertSustain Phenyl, InertSustain Phenylhexyl, InertSustain Cyano, InertSustain NH2, InertSustain Amide, InertSustainBio C18.
Your workhorse
Reprospher media are based on a 100 A ultrapure silica and are fully scalable from UPLC (1.9 µm particles) to preparative and process scale applications.
Among the offered phases there are some unique selectivities such as a wide range of aromatic specialty phases, phases with polar selectivities and unique phases for achiral SFC.
Premium performance at exceptional value
An allround and fully scalable spherical Silica from 1.5 to 15 µm with an extra high purity.
The metal content is less than 100 ppb.
The silica impresses with its very narrow pore size distribution this make 99 % of the surface accessible for the separation.
The uniform bonded phase coverage translates to symmetrical peaks for acids/bases, and predictable reversed phase selectivity.
Because of its very low metal content it also impressed with a high pH stability.
Alternative to Luna C18
A low metal content spherical silica media scalable from sub-2-micron to 10 µm particles with high carbon load for small molecules and peptides and wide pore ion exchange media for protein and enzyme analysis and purification.
Specifically designed for pharmaceutical and biotechnical separations.
A robust modern and all-purpose ultra-high purity spherical silica media scalable from UPLC to prep.
Various pore sizes are available to cover applications for small molecules up to biomolecules.
State-of-the-art surface modification technologies are employed for normal and reversed phase media including shape selective, high carbon load as well as water wettable alkyl phases.
Miniaturisation of liquid chromatography in combination with mass spectrometry has several advantages including improvements in sensitivity, especially at low concentration levels and dramatically reduced solvent consumption, compared to conventional HPLC or UHPLC. With further method optimisation, run times can also be reduced giving further savings in solvent use or time. To meet the requirements of MicroLC/CapillaryLC/NanoLC YMC offers capillary columns specifically designed to use with the corresponding chromatography systems.
Whilst historically it was the earliest form of HPLC, normal phase separations have recently received less attention due to the belief that it is complicated and unpredictable. However, normal phase chromatography is a powerful tool for the separation of positional isomers that are difficult to separate in reversed phase mode. Due to a rigid surface, compared to the more flexible carbon chains of reversed phases, the analytes are influenced by well-defined steric interaction with polar groups. YMC offers columns packed with non-bonded silica or with silica gel modified with polar groups
HILIC HPLC/UHPLC columns from YMC are rugged stationary phases which provide improved LC/ESI-MS response, direct SPE solvent compatibility and complementary selectivity to reversed phases. This is important to R&D and drug metabolism scientists since the impurity or metabolite is frequently more polar and present at much lower concentrations than the parent compound. With YMC HILIC columns, these very polar compounds elute later than the higher hydrophobic parent compound, thereby minimizing the MS ion suppression that can occur at the beginning of the chromatogram.
YMC offers several solutions for separating chiral compounds with different chiral selectors and different chiral separation mechanisms. The selectors are either coated/immobilised or bonded to the support material which has different pore sizes dependent on the selector. According to the selector chiral chromatography can be performed in NP, RP and/or SFC mode.
YMC’s selection of reversed phase (RP) UHPLC/HPLC columns
YMC-Triart,
YMC-Pack ProFamily,
YMC RP Classics,
Meteoric Core
Designed for key pharmaceutical and environmental applications, these columns utilize novel and unique chemistries to provide superior resolution with ease of use.
Want high resolution separation of water-soluble polymers? Our size exclusion columns (SEC) are available in tailored pore sizes to cover a broad range of molecular weight.
