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YMC

From headquarters located in Kyoto, Japan, YMC has gradually and consistently matured to a level of international recognition, specifically within the pharmaceutical and biotech world, as one of the leading suppliers of analytical and process-scale silica-based stationary phases for High Performance Liquid Chromatography (HPLC), preparative equipment, custom purification and method development.
Each YMC-Pack column is chromatographically tested to assure that plate count, peak symmetry and general column performance meet YMC’s high standard of quality. A column performance report is supplied with every packed column.
Each lot of YMC-Gel stationary phase is tested with a series of specific standard probes. These tests assure lot reproducibility and confirm applicability for the class of compounds for which the product is intended.

Featured (U)HPLC columns

SFC Columns

YMC offers chiral and achiral phases for supercritical fluid chromatography (SFC) applications to provide the chemist with a number of options for SFC separations. SFC can offer some advantages over HPLC for similar applications. The low viscosity of supercritical carbon dioxide allows for analytical separations 3-5 times faster than those for normal phase HPLC. Speed of the SFC separations, conservation of organic solvents, and more concentrated product fractions make SFC a desirable preparative chromatographic technique for purifying chemical mixtures. YMC’s columns are 100% compatible with SFC conditions. Further, Alcyon SFC columns are available, which are specifically packed in a SFC compatible hardware and are tested under SFC conditions.

YMC offers chiral and achiral phases for supercritical fluid chromatography (SFC) applications to provide the chemist with a number of options for SFC separations. SFC can offer some advantages over HPLC for similar applications. The low viscosity of supercritical carbon dioxide allows for analytical separations 3-5 times faster than those for normal phase HPLC. Speed of the SFC separations, conservation of organic solvents, and more concentrated product fractions make SFC a desirable preparative chromatographic technique for purifying chemical mixtures. YMC’s columns are 100% compatible with SFC conditions. Further, Alcyon SFC columns are available, which are specifically packed in a SFC compatible hardware and are tested under SFC conditions.

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BioPro HIC HT

HIC Columns for High Throughput Analyses Ideal drug-to-antibody ratio (DAR) analysis due to novel surface chemistry High throughput by reducing analysis time Excellent batch-to-batch reproducibility

HIC Columns for High Throughput Analyses
Ideal drug-to-antibody ratio (DAR) analysis due to novel surface chemistry
High throughput by reducing analysis time
Excellent batch-to-batch reproducibility

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Biocompatible YMC-Triart metal-free

Inert columns for bio separations and coordinating compounds Excellent peak shapes and high sensitivity Reproducible results day-after-day No carry-over effects Ideal for highly sensitive LC/MS analyses High pressure limits Ideal choice for Sensitive proteins or peptides, Nucleotides, oligonucleotides, Metal coordinating compounds

Inert columns for bio separations and coordinating compounds
Excellent peak shapes and high sensitivity
Reproducible results day-after-day
No carry-over effects
Ideal for highly sensitive LC/MS analyses
High pressure limits
Ideal choice for Sensitive proteins or peptides, Nucleotides, oligonucleotides, Metal coordinating compounds

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Analytical (U)HPLC columns

Micro/NanoLC Columns

Miniaturisation of liquid chromatography in combination with mass spectrometry has several advantages including improvements in sensitivity, especially at low concentration levels and dramatically reduced solvent consumption, compared to conventional HPLC or UHPLC. With further method optimisation, run times can also be reduced giving further savings in solvent use or time. To meet the requirements of MicroLC/CapillaryLC/NanoLC YMC offers capillary columns specifically designed to use with the corresponding chromatography systems.

Normal Phase (NP) Columns

Whilst historically it was the earliest form of HPLC, normal phase separations have recently received less attention due to the belief that it is complicated and unpredictable. However, normal phase chromatography is a powerful tool for the separation of positional isomers that are difficult to separate in reversed phase mode. Due to a rigid surface, compared to the more flexible carbon chains of reversed phases, the analytes are influenced by well-defined steric interaction with polar groups. YMC offers columns packed with non-bonded silica or with silica gel modified with polar groups

HILIC Columns

HILIC HPLC/UHPLC columns from YMC are rugged stationary phases which provide improved LC/ESI-MS response, direct SPE solvent compatibility and complementary selectivity to reversed phases. This is important to R&D and drug metabolism scientists since the impurity or metabolite is frequently more polar and present at much lower concentrations than the parent compound. With YMC HILIC columns, these very polar compounds elute later than the higher hydrophobic parent compound, thereby minimizing the MS ion suppression that can occur at the beginning of the chromatogram.

Chiral Columns

YMC offers several solutions for separating chiral compounds with different chiral selectors and different chiral separation mechanisms. The selectors are either coated/immobilised or bonded to the support material which has different pore sizes dependent on the selector. According to the selector chiral chromatography can be performed in NP, RP and/or SFC mode.

Biochromatography Columns

RP Bioseparation,
Ion Exchange (IEX),
Size Exclusion (SEC),
Hydrophobic Interaction (HIC)

Reversed Phase (RP) Columns

YMC’s selection of reversed phase (RP) UHPLC/HPLC columns
YMC-Triart,
YMC-Pack ProFamily,
YMC RP Classics,
Meteoric Core