{"id":1468,"date":"2026-04-03T11:05:30","date_gmt":"2026-04-03T08:05:30","guid":{"rendered":"https:\/\/metrolab.cen.aboutdev.gr\/?p=1468"},"modified":"2026-04-30T13:29:41","modified_gmt":"2026-04-30T10:29:41","slug":"hilic-columns","status":"publish","type":"post","link":"https:\/\/metrolab.gr\/en\/hilic-columns\/","title":{"rendered":"HILIC Columns"},"content":{"rendered":"

HILIC HPLC\/UHPLC columns from YMC are rugged stationary phases which provide improved LC\/ESI-MS response, direct SPE solvent compatibility and complementary selectivity to reversed phases. This is important to R&D and drug metabolism scientists since the impurity or metabolite is frequently more polar and present at much lower concentrations than the parent compound. With YMC HILIC columns, these very polar compounds elute later than the higher hydrophobic parent compound, thereby minimizing the MS ion suppression that can occur at the beginning of the chromatogram.<\/p>","protected":false},"excerpt":{"rendered":"

HILIC HPLC\/UHPLC columns from YMC are rugged stationary phases which provide improved LC\/ESI-MS response, direct SPE solvent compatibility and complementary selectivity to reversed phases. This is important to R&D and drug metabolism scientists since the impurity or metabolite is frequently more polar and present at much lower concentrations than the parent compound. With YMC HILIC columns, these very polar compounds elute later than the higher hydrophobic parent compound, thereby minimizing the MS ion suppression that can occur at the beginning of the chromatogram.<\/p>","protected":false},"author":2,"featured_media":1455,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[57],"tags":[109],"class_list":["post-1468","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ymc","tag-category"],"acf":[],"yoast_head":"\nHILIC Columns - MetroLab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/metrolab.gr\/en\/hilic-columns\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HILIC Columns - MetroLab\" \/>\n<meta property=\"og:description\" content=\"HILIC HPLC\/UHPLC columns from YMC are rugged stationary phases which provide improved LC\/ESI-MS response, direct SPE solvent compatibility and complementary selectivity to reversed phases. This is important to R&D and drug metabolism scientists since the impurity or metabolite is frequently more polar and present at much lower concentrations than the parent compound. With YMC HILIC columns, these very polar compounds elute later than the higher hydrophobic parent compound, thereby minimizing the MS ion suppression that can occur at the beginning of the chromatogram.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/metrolab.gr\/en\/hilic-columns\/\" \/>\n<meta property=\"og:site_name\" content=\"MetroLab\" \/>\n<meta property=\"article:published_time\" content=\"2026-04-03T08:05:30+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-30T10:29:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/metrolab.gr\/wp-content\/uploads\/2026\/04\/YMC_07.-HILIC-columns_2021.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"290\" \/>\n\t<meta property=\"og:image:height\" content=\"195\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"praktiki\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"praktiki\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/metrolab.gr\\\/hilic-columns\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/metrolab.gr\\\/hilic-columns\\\/\"},\"author\":{\"name\":\"praktiki\",\"@id\":\"https:\\\/\\\/metrolab.gr\\\/#\\\/schema\\\/person\\\/b98de2eb332dfc3d427dc3608e835c04\"},\"headline\":\"HILIC Columns\",\"datePublished\":\"2026-04-03T08:05:30+00:00\",\"dateModified\":\"2026-04-30T10:29:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/metrolab.gr\\\/hilic-columns\\\/\"},\"wordCount\":89,\"publisher\":{\"@id\":\"https:\\\/\\\/metrolab.gr\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/metrolab.gr\\\/hilic-columns\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/metrolab.gr\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/YMC_07.-HILIC-columns_2021.jpg\",\"keywords\":[\"category\"],\"articleSection\":[\"YMC\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/metrolab.gr\\\/hilic-columns\\\/\",\"url\":\"https:\\\/\\\/metrolab.gr\\\/hilic-columns\\\/\",\"name\":\"HILIC Columns - MetroLab\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/metrolab.gr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/metrolab.gr\\\/hilic-columns\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/metrolab.gr\\\/hilic-columns\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/metrolab.gr\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/YMC_07.-HILIC-columns_2021.jpg\",\"datePublished\":\"2026-04-03T08:05:30+00:00\",\"dateModified\":\"2026-04-30T10:29:41+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/metrolab.gr\\\/hilic-columns\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/metrolab.gr\\\/hilic-columns\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/metrolab.gr\\\/hilic-columns\\\/#primaryimage\",\"url\":\"https:\\\/\\\/metrolab.gr\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/YMC_07.-HILIC-columns_2021.jpg\",\"contentUrl\":\"https:\\\/\\\/metrolab.gr\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/YMC_07.-HILIC-columns_2021.jpg\",\"width\":290,\"height\":195},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/metrolab.gr\\\/hilic-columns\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/metrolab.gr\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"HILIC Columns\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/metrolab.gr\\\/#website\",\"url\":\"https:\\\/\\\/metrolab.gr\\\/\",\"name\":\"MetroLab\",\"description\":\"\u0388\u03bd\u03b1\u03c2 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03ac\u03c4\u03b7\u03c2, \u03c7\u03b9\u03bb\u03b9\u03ac\u03b4\u03b5\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03cc \u03c3\u03b1\u03c2\",\"publisher\":{\"@id\":\"https:\\\/\\\/metrolab.gr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/metrolab.gr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/metrolab.gr\\\/#organization\",\"name\":\"MetroLab\",\"url\":\"https:\\\/\\\/metrolab.gr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/metrolab.gr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/metrolab.gr\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/logo_metrolab-1@2x-1.png\",\"contentUrl\":\"https:\\\/\\\/metrolab.gr\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/logo_metrolab-1@2x-1.png\",\"width\":409,\"height\":108,\"caption\":\"MetroLab\"},\"image\":{\"@id\":\"https:\\\/\\\/metrolab.gr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/metrolab.gr\\\/#\\\/schema\\\/person\\\/b98de2eb332dfc3d427dc3608e835c04\",\"name\":\"praktiki\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a717692306270715324e48aa870b6be5b99691d4444d8bb03ece104d00acd956?s=96&d=monsterid&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a717692306270715324e48aa870b6be5b99691d4444d8bb03ece104d00acd956?s=96&d=monsterid&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a717692306270715324e48aa870b6be5b99691d4444d8bb03ece104d00acd956?s=96&d=monsterid&r=g\",\"caption\":\"praktiki\"},\"url\":\"https:\\\/\\\/metrolab.gr\\\/en\\\/author\\\/praktiki\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"HILIC Columns - MetroLab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/metrolab.gr\/en\/hilic-columns\/","og_locale":"en_GB","og_type":"article","og_title":"HILIC Columns - MetroLab","og_description":"HILIC HPLC\/UHPLC columns from YMC are rugged stationary phases which provide improved LC\/ESI-MS response, direct SPE solvent compatibility and complementary selectivity to reversed phases. This is important to R&D and drug metabolism scientists since the impurity or metabolite is frequently more polar and present at much lower concentrations than the parent compound. With YMC HILIC columns, these very polar compounds elute later than the higher hydrophobic parent compound, thereby minimizing the MS ion suppression that can occur at the beginning of the chromatogram.","og_url":"https:\/\/metrolab.gr\/en\/hilic-columns\/","og_site_name":"MetroLab","article_published_time":"2026-04-03T08:05:30+00:00","article_modified_time":"2026-04-30T10:29:41+00:00","og_image":[{"width":290,"height":195,"url":"https:\/\/metrolab.gr\/wp-content\/uploads\/2026\/04\/YMC_07.-HILIC-columns_2021.jpg","type":"image\/jpeg"}],"author":"praktiki","twitter_card":"summary_large_image","twitter_misc":{"Written by":"praktiki"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/metrolab.gr\/hilic-columns\/#article","isPartOf":{"@id":"https:\/\/metrolab.gr\/hilic-columns\/"},"author":{"name":"praktiki","@id":"https:\/\/metrolab.gr\/#\/schema\/person\/b98de2eb332dfc3d427dc3608e835c04"},"headline":"HILIC Columns","datePublished":"2026-04-03T08:05:30+00:00","dateModified":"2026-04-30T10:29:41+00:00","mainEntityOfPage":{"@id":"https:\/\/metrolab.gr\/hilic-columns\/"},"wordCount":89,"publisher":{"@id":"https:\/\/metrolab.gr\/#organization"},"image":{"@id":"https:\/\/metrolab.gr\/hilic-columns\/#primaryimage"},"thumbnailUrl":"https:\/\/metrolab.gr\/wp-content\/uploads\/2026\/04\/YMC_07.-HILIC-columns_2021.jpg","keywords":["category"],"articleSection":["YMC"],"inLanguage":"en-GB"},{"@type":"WebPage","@id":"https:\/\/metrolab.gr\/hilic-columns\/","url":"https:\/\/metrolab.gr\/hilic-columns\/","name":"HILIC Columns - MetroLab","isPartOf":{"@id":"https:\/\/metrolab.gr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/metrolab.gr\/hilic-columns\/#primaryimage"},"image":{"@id":"https:\/\/metrolab.gr\/hilic-columns\/#primaryimage"},"thumbnailUrl":"https:\/\/metrolab.gr\/wp-content\/uploads\/2026\/04\/YMC_07.-HILIC-columns_2021.jpg","datePublished":"2026-04-03T08:05:30+00:00","dateModified":"2026-04-30T10:29:41+00:00","breadcrumb":{"@id":"https:\/\/metrolab.gr\/hilic-columns\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/metrolab.gr\/hilic-columns\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/metrolab.gr\/hilic-columns\/#primaryimage","url":"https:\/\/metrolab.gr\/wp-content\/uploads\/2026\/04\/YMC_07.-HILIC-columns_2021.jpg","contentUrl":"https:\/\/metrolab.gr\/wp-content\/uploads\/2026\/04\/YMC_07.-HILIC-columns_2021.jpg","width":290,"height":195},{"@type":"BreadcrumbList","@id":"https:\/\/metrolab.gr\/hilic-columns\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/metrolab.gr\/en\/"},{"@type":"ListItem","position":2,"name":"HILIC Columns"}]},{"@type":"WebSite","@id":"https:\/\/metrolab.gr\/#website","url":"https:\/\/metrolab.gr\/","name":"MetroLab","description":"\u0388\u03bd\u03b1\u03c2 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03ac\u03c4\u03b7\u03c2, \u03c7\u03b9\u03bb\u03b9\u03ac\u03b4\u03b5\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03cc \u03c3\u03b1\u03c2","publisher":{"@id":"https:\/\/metrolab.gr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/metrolab.gr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/metrolab.gr\/#organization","name":"MetroLab","url":"https:\/\/metrolab.gr\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/metrolab.gr\/#\/schema\/logo\/image\/","url":"https:\/\/metrolab.gr\/wp-content\/uploads\/2026\/03\/logo_metrolab-1@2x-1.png","contentUrl":"https:\/\/metrolab.gr\/wp-content\/uploads\/2026\/03\/logo_metrolab-1@2x-1.png","width":409,"height":108,"caption":"MetroLab"},"image":{"@id":"https:\/\/metrolab.gr\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/metrolab.gr\/#\/schema\/person\/b98de2eb332dfc3d427dc3608e835c04","name":"praktiki","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/a717692306270715324e48aa870b6be5b99691d4444d8bb03ece104d00acd956?s=96&d=monsterid&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/a717692306270715324e48aa870b6be5b99691d4444d8bb03ece104d00acd956?s=96&d=monsterid&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a717692306270715324e48aa870b6be5b99691d4444d8bb03ece104d00acd956?s=96&d=monsterid&r=g","caption":"praktiki"},"url":"https:\/\/metrolab.gr\/en\/author\/praktiki\/"}]}},"_links":{"self":[{"href":"https:\/\/metrolab.gr\/en\/wp-json\/wp\/v2\/posts\/1468","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/metrolab.gr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/metrolab.gr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/metrolab.gr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/metrolab.gr\/en\/wp-json\/wp\/v2\/comments?post=1468"}],"version-history":[{"count":1,"href":"https:\/\/metrolab.gr\/en\/wp-json\/wp\/v2\/posts\/1468\/revisions"}],"predecessor-version":[{"id":1469,"href":"https:\/\/metrolab.gr\/en\/wp-json\/wp\/v2\/posts\/1468\/revisions\/1469"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/metrolab.gr\/en\/wp-json\/wp\/v2\/media\/1455"}],"wp:attachment":[{"href":"https:\/\/metrolab.gr\/en\/wp-json\/wp\/v2\/media?parent=1468"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/metrolab.gr\/en\/wp-json\/wp\/v2\/categories?post=1468"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/metrolab.gr\/en\/wp-json\/wp\/v2\/tags?post=1468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}